Methods of Analysis and Identification of Betulin and Its Derivatives / Altynaray T. Takibayeva, Gulistan K. Zhumabayeva, Abdigali A. Bakibaev [et al.]

Set Level: Molecules, Basel, MDPI AGCoauthor: Takibaeva, A. T.;Zhumabaeva, G. K., Gulistan;Bakibaev, A. A., Russian chemist, Professor of TPU, doctor of chemical sciences, 1960-, Abdigali Abdimanapovich;Demets, O. V., Olga;Lyapunova, M. V., Mariya Viktorovna;Mamaeva, E. A., Chemist, Associate Professor of Tomsk Polytechnic University, Candidate of chemical sciences, 1975-, Elena Andreevna;Yerkassov, R. Sh., Rakhmetulla Sharapidenovich;Kassenov, R. Zh.;Ibraev, M. K., Marat KirimbaevichLanguage: английский.Country: Switzerland.Abstract: This scientific work presents practical and theoretical material on the methods of analysis and identification of betulin and its key derivatives. The properties of betulin and its derivatives, which are determined by the structural features of this class of compounds and their tendency to form dimers, polymorphism and isomerization, are considered. This article outlines ways to improve not only the bioavailability but also the solubility of triterpenoids, as well as any hydrophobic drug substances, through chemical transformations by introducing various functional groups, such as carboxyl, hydroxyl, amino, phosphate/phosphonate and carbonyl. The authors of this article summarized the physicochemical characteristics of betulin and its compounds, systematized the literature data on IR and NMR spectroscopy and gave the melting temperatures of key acids and aldehydes based on betulin.Bibliography: References: 120 tit.Subject: электронный ресурс | труды учёных ТПУ | betulin | the solubility of pentacyclic triterpenoids | bioavailability | chemical transformation Online Resources:https://doi.org/10.3390/molecules28165946
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References: 120 tit

This scientific work presents practical and theoretical material on the methods of analysis and identification of betulin and its key derivatives. The properties of betulin and its derivatives, which are determined by the structural features of this class of compounds and their tendency to form dimers, polymorphism and isomerization, are considered. This article outlines ways to improve not only the bioavailability but also the solubility of triterpenoids, as well as any hydrophobic drug substances, through chemical transformations by introducing various functional groups, such as carboxyl, hydroxyl, amino, phosphate/phosphonate and carbonyl. The authors of this article summarized the physicochemical characteristics of betulin and its compounds, systematized the literature data on IR and NMR spectroscopy and gave the melting temperatures of key acids and aldehydes based on betulin

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