Bacterial inhibition and biofilm eradication ability of low-toxic deep eutectic solvents prepared from lactic acid and quaternary ammonium compounds / Gleb E. Dubinenko, Alexandra E. Myshova, Olga A. Igumnova [et al.]

Set Level: Materials Letters, Amsterdam, Elsevier Science Publishing Company Inc.Coauthor: Dubinenko, G. E., Specialist in the field of material science, Engineer of Tomsk Polytechnic University, 1992-, Gleb Evgenjevich;Myshova, Aleksandra (Alexandra) Evgenjevna, А. Е., 2000-, specialist in the field of biotechnology, Engineer of Tomsk Polytechnic University;Igumnova, O. A., Olga Alekseevna;Golovina, Kseniya Sergeevna, K. S., 2000-, specialist in the field of biotechnology, Engineer of Tomsk Polytechnic University;Plotnikov, E. V., chemist, Associate Professor of Tomsk Polytechnic University, Candidate of Chemical Sciences, 1983-, Evgeny Vladimirovich;Badaraev, A. D., Physicist, Engineer of Tomsk Polytechnic University, 1995-, Arsalan Dorzhievich;Rutkowski, S., chemist, Research Engineer, Tomsk Polytechnic University, Ph.D, 1981-, Sven;Filimonov, V. D., Russian chemist, Professor of the TPU, 1945-, Viktor Dmitrievich;Tverdokhlebov, S. I., physicist, Associate Professor of Tomsk Polytechnic University, Candidate of physical and mathematical science, 1961-, Sergei IvanovichCorporate Author (Secondary): Томский политехнический университет, 1991-Language: английский.Country: Netherlands.Abstract: In the present communication, the preparation of deep eutectic solvents (DESs) based on an aqueous solution of lactic acid (LA) and two different quaternary ammonium compounds, choline chloride (ChCl) and tetraethylammonium chloride (TEAC), is proposed for the application as an antibacterial agent. The antibacterial and cytotoxic properties of the DESs obtained were studied and found to be highly effective in inhibiting both Gram-positive and Gram-negative bacteria and eradicating bacterial biofilms. Moreover, the DESs obtained exhibited reduced cytotoxicity towards soft tissue cells compared to the aqueous LA solution. The excellent antibacterial properties and low cytotoxicity of the DESs prepared make them a promising candidate for the development of novel antimicrobial agents or antibacterial eutectogels for delivery systems and tissue engineering applications.Bibliography: References: 8 tit..Subject: Deep eutectic solvents | Lactic acid | Quaternary ammonium compounds | Choline chloride | Tetraethylammonium chloride | Antibacterial | Biocompatible | электронный ресурс | труды учёных ТПУ Online Resources:https://doi.org/10.1016/j.matlet.2024.137591
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References: 8 tit.

In the present communication, the preparation of deep eutectic solvents (DESs) based on an aqueous solution of lactic acid (LA) and two different quaternary ammonium compounds, choline chloride (ChCl) and tetraethylammonium chloride (TEAC), is proposed for the application as an antibacterial agent. The antibacterial and cytotoxic properties of the DESs obtained were studied and found to be highly effective in inhibiting both Gram-positive and Gram-negative bacteria and eradicating bacterial biofilms. Moreover, the DESs obtained exhibited reduced cytotoxicity towards soft tissue cells compared to the aqueous LA solution. The excellent antibacterial properties and low cytotoxicity of the DESs prepared make them a promising candidate for the development of novel antimicrobial agents or antibacterial eutectogels for delivery systems and tissue engineering applications

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