Synthesis and Properties of a Water-Soluble Ureide Derived from Gаlodif and Succinic Acid / V. Yu. Kuksenok, Y. Cui, V. V. Shtrykova [et al.]
Set Level: Russian Journal of Organic Chemistry, New York, Springer Science+Business Media LLC.Language: английский.Country: США.Abstract: A new ureide has been synthesized by acylation of the anticonvulsant and anti-alcohol drug galodif N-[(3-chlorophenyl)(phenyl)methyl]urea with succinic anhydride in the presence of some acids. Unlike galodif which is almost insoluble in water, the synthesized ureide is soluble in aqueous media. It is expected to exhibit higher bioavailability and is promising as a liquid drug dosage form and a prodrug with prolonged action.Bibliography: References: 14 tit.Subject: электронный ресурс | труды учёных ТПУ | acylation of ureas | galodif | benzhydrylureas | ureides | succinic acid | anticonvulsants Online Resources:https://doi.org/10.1134/S1070428023090221Title screen
References: 14 tit
A new ureide has been synthesized by acylation of the anticonvulsant and anti-alcohol drug galodif N-[(3-chlorophenyl)(phenyl)methyl]urea with succinic anhydride in the presence of some acids. Unlike galodif which is almost insoluble in water, the synthesized ureide is soluble in aqueous media. It is expected to exhibit higher bioavailability and is promising as a liquid drug dosage form and a prodrug with prolonged action
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